|
KMID : 0043320010240030249
|
|
Archives of Pharmacal Research
2001 Volume.24 No. 3 p.249 ~ p.255
|
|
|
Antiallergic Action of Magnolia Officinalis on Immediate Hypersensitivity Reaction
|
|
Shin TY
Kim DK/Chae BS/Lee EJ
|
|
|
Abstract
|
|
|
|
We studied the effect of aqueou extract of Magnolia officinalis bark (Magnoliaceae) (MOAE) on the immediate hypersensitivity reaction. MOAE (0.O1 to 1g/kg) dose-depen- dently inhibited compound 48/80 induced systemic Anaphylaxis in rats. MOAE (0.1 aud 1 g/kg) also significantly inhibited local immunoglobulin E (lgE)-mediated passive cutaneous anaphylactic reaction. When MOAE was pretreated at concentrations ranging from 0.01 to 1g/kg, the levels of plasma histamine were reduced in a dose-dependent manner. MOAE (0.001 to 1mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 47/80 or anti-dintrophenyl (DNP) lgE. The level of cyclic AMP (cAMP) in RPMC, when MOAE was added, significant increased compared with that of the normal control. Moreoverf MOAE (0.01 to 1mg/ml) had a significant inhibitory effect on anti-DNP lgE-induced tumor necrosis factor-alpha production from RPMC. These results indicate that MOAE inhibits immediate hypersensitivity reaction in vivo and in vitro.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|